Combined NLS study of space-occupying lesions of ocular organs

There are presented results of the complex NLS-research of patients with space-occupying lesions of orbital and extra-orbital genesis which were confirmed by the results of the clinical research, MRT and CT scanning and also morphologically verified in patients who had underwent surgery. It is determined that spectral-entropic analysis of tissues structure of spectral parameters of blood circulation in feeding vessels substantially helps during corrective diagnostics of the eye tumors. 3D NLS-reconstruction allows accurate stating the syntopy of a neoplasm and its relation with the surrounding tissues on a real time basis. NLS-ultramicroscanning is one of the effective methods in determination of neoplasm types. As a result of performed work the advantage of full-scale 3D study is demonstrated in comparison with traditional 2D NLS-graphy. 

Over the last years there is a steady increase tendency of malignant neoplasms formation in eye tumors despite its insignificance in the structure of oncological pathology. It should be noted that the problem of an early diagnostics of oncoophthalmological pathology has its own peculiarities in the different countries. Retinoblastoma in particular is the most spread congenital and acquired oncological disease. Among 450-500 thousands of examined patients there are 20-30 firstly diagnosticated cases of retinoblastoma registered every year in USA. These retinoblastoma cases differ by their aggressive growth rate and they cause metastasis, invalidity and lethality if untimely diagnosed.

There are certain difficulties in the diagnostics of malignant orbital and extra-orbital neoplasms related to the complexity of topographic-anatomic features of the head, type and growth rate of the tumor. In ophthalmological practice it is both necessary to detect neoplasm and also to evaluate the rate of process prevalence in surrounding tissues, change of the vessels that feed the tumor. It is known that many brain diseases, supramaxillary and ethmoidal cells and also endocrine diseases are accompanied by the syndrome of unilateral or bilateral exophthalmos. In many cases such syndrome rouses an assumption for oncological pathology of eyes.

Modern ophthalmoscopic and roentgenologic methods not always allow dealing with the problems of topographical diagnostics of tumors. Over the last years there were some reports concerning diagnostic capabilities of CT, MRT in case of eye and orbital cavity neoplasms. But the large-scale implementation of abovementioned research methods of eyes and orbital cavity depends largely on their availability.

In this regard the use of modern techniques of non-linear diagnostics (NLS) for detection, differential and corrective diagnostics of eyes and extraorbital neoplasms is closely followed by the researches. Implementation of non-linear ophthalmography into clinical practice actually reflects all the periods of tool engineering development and improvement of the technologies in this regard. There were no detailed studies of diagnostic capabilities of NLS-graphy in case of neoplasms in ocular organs.

 In case of assumption of eyes neoplasms ophthalmologists deal not only with the detection of their organ affiliation but also with rational evaluation of blood circulation. In this regard 3D NLS- angiography offers great opportunities in oncological ophthalmology.

The goal of given report is experience interchange of clinical application of 3D NLS-graphy in full assessment of eyes and orbital cavities neoplasms.